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Nitric oxide supplements are a class of health products to increase nitric oxide production. They generally use a mixture of ingredients such as citrulline, Arginine, beta-alanine, BCAAs, taurine, tyrosine, and more. We will discuss these ingredients in the following section.

Nitric oxide is a natural molecule that is naturally produced in our own body. It helps to facilitate communication between cells by transmitting signals in our body.

Nitric oxide, commonly referred to as “NO,” is used for a wide variety of purposes within the body, but it is essential primarily for its strength and endurance enhancing properties.

Nitric oxide is essential for blood vessels health and important compound for vasodilatation. Nitric oxide helps to relax the blood vessel’s inner muscles. Widen muscles of blood vessels improve blood circulation and lowers blood pressure

Nitric oxide plays a vital role in the physiology and the pathophysiology of many organ systems of our body.

The best-rated Nitric Oxide Supplements 2019 are:

  • BSN Nitrix 2.0
  • BulkSupplements L-Arginine a-Ketoglutarate (AAKG) Powder
  • HEART 360 Nu-Life Supplements
  • Muscle X Boost- Premium L-Arginine Formula
  • Nitric Oxide Supplement by Zhou Nutrition

Nitric oxide is essential for effective and efficient blood flow the organs of the human body and enhance overall health.

Naturally, enzymes of the body break down Arginine (from food such as shrimp, crab, spinach & turkey) to produce nitric oxide. Nitric oxide supplements contain compounds such as Arginine or nitrate, which our body breakdown to produce nitric oxide. It provides many health and performance benefits.

Best Nitric Oxide Supplements Reviews 2019

There are many nitric oxide supplements in the market. To help you find the best nitric oxide supplement, have compiled the list of some the best available in the market.

Before you take any supplements, it is essential to consult your health professional.

BSN NITRIX 2.0, 90 tablets

BSN Nitrix 2.0 is a powerful nitric oxide supplement that combines L-Citrulline, Hawthorne Extract, Creatine and more to provide a powerful exercise enhancer in a convenient package.

Nitrix 2.0 is a powerful all-round training amplifier and one of our top recommendations.


  • Loaded with L-Citrulline, Creatine and more
  • Uses three different types of creatine
  • Easy to take
  • Good value

BulkSupplements L-Arginine a-Ketoglutarate (AAKG) Powder

This supplement by BulkSupplements contains 500 grams of AAKG (L-Arginine a-Ketoglutarate) powder. This nitric oxide supplement enhances nitric oxide levels of body and helps to provide nutrients to your muscles. It is recommended to not take this supplement for more than 80 consecutive days.

This supplement has clean and pure AAKG powder and no fillers. They come in the factory-sealed foil zip pouch and are lab-tested for guaranteed purity. According to manufacturer recommended dosage is 2600 mg (1 teaspoon) on an empty stomach up to 3 times a day.

HEART 360 by Nu-Life Supplements

HEART 360 by Nu-Life supplements contains the blend of amino acids, L-citrulline, and L-Arginine for nitric oxide production in the body.

This supplement has the number of benefits such as improved blood circulation, muscle development and increases energy. 

This nitric oxide supplement comes in strawberry-kiwi flavor and manufacturer provides 30 days money back guarantee. 

Muscle X Boost- Premium L-Arginine Formula

This nitric oxide by muscle X boost has L-Arginine and L-Citrulline to fuel nitric oxide production.

It helps to improve performance for the workout by giving enough power and fuel.

Nitric Oxide Supplement by Zhou Nutrition

This Nitric Oxide Supplement consists of ingredients such as L Arginine, AAKG, Citrulline Malate, and Beet Root. All these ingredients boost your performance by giving more stamina, and energy.

This nitric oxide supplement by Zhou nutrition is gluten-free and non-GMO. They come in the pack with 120 capsules. According to the manufacturer, you can take 4 capsules in 1 serving, 30 minutes before workout. It is also recommended to take the maximum of 2 serving in a day.

Zhou nutrition also has 30 days money back guarantee if you are not satisfied with the results of this product.

Best Nitric Oxide Supplements Buyers Guide

What are Nitric Oxide Supplements?

In general, NO supplements consist mixture of ingredients to increase your nitric oxide levels in our body. Nitric oxide supplements helps to improve duration, quality and intensity of your workout for better results.

Nitric oxide is essential for the health and performance of our body. Inadequate nitric oxide in the body is often associated with diabetes, erectile dysfunction, and heart disease.

There are also natural ways to increase the production of nitric acid in the body, which we will mention below.

The optimal level of nitric oxide in the body is essential for overall health. If your body is not able to produce required nitric oxide, then nitric oxide supplement may help you.

What are the typical ingredients in nitric oxide supplements?

As already mentioned, nitric oxide products use mixtures of several ingredients.

  • Arginine
  • Citrulline
  • Branched Chain Amino Acids
  • Beta-Alanine
  • Creatine


This semi-essential amino acid is an essential ingredient in virtually every nitric oxide supplement. 

Arginine is the amino acid with a high amount of nitrogen. Foods such as nuts, legumes, eggs or chicken breasts are rich in arginine

In NO Boosters, arginine is in the form of arginine alpha-ketoglutarate (AAKG). 


Another amino acid in Nitric oxide Boosters is Citrulline. 

Our body partly converts Citrulline to arginine. It is even able to raise arginine levels higher than arginine itself. 

In NO supplements or individual supplement, citrulline malate is the common ingredient.

Citrulline malate is the amino acid citrulline esterifies with malate (the salts of malic acid).


BCAAs (branched-chain amino acids) are essential amino acids for the human body. They are a common ingredient in Nitric oxide supplements and are even available as individual supplements.


This amino acid has become popular in recent years as supplements for bodybuilding or weight training. 

It is responsible for the tingling sensation that some pump supplements cause and has become indispensable in any good NO booster.


Creatine increases performance during short, high-intensity exercise with a daily intake of just 3 grams. 

Creatine is beneficial for bodybuilding and strength training. 

Vitamins and minerals

Vitamins such as B vitamins and minerals such as magnesium, sodium, potassium or calcium are often a common ingredient in the good NO supplements.

What are the benefits of Nitric Oxide?

There are lots of studies on nitric oxide in the last 20 years. Nitric oxide plays essential roles in the way our body cells communicate with each other.

Some of the benefits of nitric oxide supplements are as following

Heart disease

Most nitric oxide supplements contain amino acid arginine, which is used by our body to produce Nitric oxide. It helps blood vessels to relax and improve circulation as nitric oxide is a powerful neurotransmitter.

Improved blood circulation in arteries of the heart can be beneficial for coronary artery disease, clogged arteries, and angina.


People with type 2 diabetes are unable to produce the optimum level of nitric oxide. There are many complications of diabetes, such as stroke, kidney failure, and heart disease. It happens because of poor vessel health and accumulation of fatty deposits in the arteries.

According to a study, researchers found that Nitric oxide supplements can enhance nitric oxide production in body and help in diabetes treatment and disease prevention.

It also helps in better sugar control as it increases insulin sensitivity.

Although until future research is done, it is premature to conclude the effect of nitric oxide supplements in the treatment of diabetes.

Blood pressure

High blood pressure can cause health issues such as kidney failure and heart disease over time. High blood pressure means stress on your arteries by force of blood pushing against blood vessels wall is higher than it should be.

There are many factors which can cause high blood pressure or hypertension. Physical inactivity, diabetes, overweight, high cholesterol, unhealthy food, and smoking are some of the reasons.

Nitric oxide supplements help blood vessels to dilate and relax. Improved blood circulation after that helps to lower the blood pressure.

Diets which are high in fruits and vegetables help in decreasing blood pressure. Also, beetroot and Dark leafy greens like spinach are good for blood pressure. They contain nitrate which our body uses to produce nitric oxide.

Exercise performance

Nitric oxide helps blood vessels to relax and improves blood circulation. Wider blood vessels enhance the flow of nutrition and oxygen to the working muscles. It therefore boosts and enhances the performance of working muscles during exercise.

Nitric oxide supplements contain ingredients such as amino acids L-arginine or nitrate. They are used by our body to increase nitric oxide. These supplements are nowadays trendy among athletes, gym-goers, swimmers, runners, and cyclists.

If you are taking nitric oxide as a performance enhancer, then choose the one with nitrate or L-citrulline. L-arginine is broken down more quickly in comparison to others.

Erectile dysfunction

Production of nitric oxide with nitric oxide supplements which contain amino acid L-citrulline may help in the treatment of erectile dysfunction.

Nitric oxide relaxes the muscles and improves blood circulation in chambers inside the penis.

Researchers found that L-citrulline is less efficient but safer than Viagra, which is prescribed the drug for erectile dysfunction.

Nitric oxide supplements, which include L-citrulline, L-arginine, and Pycnogenol (plant extract from the pine tree) have shown the promising result for ED.

Muscle soreness

Muscle soreness can occur after strenuous exercise. This uncomfortable soreness usually feels strongest after 24-72 hours of training.

Nitric oxide supplements can increase the blood to active muscles, which increase nutrient delivery. It also clears waste product such as ammonia and lactate, which causes muscle fatigue.

The amount of dosage and exercise you perform can affect the ability of nitric oxide supplement. Further research is needed to determine the effect of nitric oxide for muscle soreness.

Are there any side effects of Nitric Oxide?


Nitric oxide supplements are considered safe to use with minor side effects up to 3 months.

Since our body naturally produces nitric oxide, it is recommended to take only the appropriate amount.

We recommend you to consult the doctor if you are taking any other medication to lower blood pressure or to treat erectile dysfunction.

If you are pregnant or nursing, then never take any supplements before consulting your doctor first.

Some minor side effects of nitric oxide supplements are as following

  • Bloating and abdominal pain
  • Gout
  • Diarrhea
  • Dark red-colored urine or stool if your nitric oxide supplement has beetroot juice.

How to increase nitric oxide in the body naturally

Nitric oxide is a compound in which our body produces naturally. There are many natural ways to ensure that your body maintains the optimal level of nitric oxide.


Vegetables with high nitrate are an excellent source for your body to produce nitric oxide. When nitrate-rich vegetables are consumed, our body converts nitrate into nitric acid.

Consuming nitrate-rich vegetables have many health benefits, such as lowering blood pressure and improving exercise performance.

Some of the common vegetables high in nitrate are:

  • Spinach
  • Celery
  • Lettuce
  • Beetroot
  • Cress
  • Arugula


Exercise is an excellent way to improve health. Exercise improves endothelial function, which keeps blood vessels healthy. With training, a thin layer of cells inside blood vessels produces nitric oxide. Without insufficient nitric oxide production in the body, there is the risk of many health problems.

With regular exercise, you can improve nitric oxide production in less than ten weeks.


Our mouth has many kinds of bacteria’s; some of them are beneficial. Mouthwash helps you in reducing the growth of cavities by killing all oral bacteria. In this process, we lose beneficial bacteria’s too. There are certain bacteria’s which are needed to convert nitrate to nitric oxide.

According to research on the use of mouthwash, it kills bacteria’s needed for nitric oxide for up to 12 hours.


Nitric oxides quickly degrade in the bloodstream as they are unstable molecules. Antioxidant limits the breakdown and increases the stability of nitric oxide.

Antioxidants need to extend the life of nitric oxide in your body is found in vegetables, fruits, seeds, nuts, and grains.

Some important antioxidants are:

Vitamin E: This antioxidant keeps the immune system healthy. Free radicals in the body contribute to disease and ageing. Vitamin E helps to protect cells from these free radicals.

Vitamin C: It helps the body to form connective tissues such as tendons, cartilage, bones, and skin.

Glutathione: It is naturally produced in the liver and typically found in fruits, vegetables, and meat. Glutathione is needed for tissue repair and building, for the immune system and for making proteins required in the body.

Polyphenols: This category of antioxidants has many potential health benefits. They are known for their effectiveness in combating cell damage.